Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development.RasGRP1 is important in some cancers and autoimmune diseases but, in PERMED/COLOUR TREATED CONDITIONER contrast to SOS, its regulatory mechanisms are poorly understood.Activating signals lead to the membrane recruitment of RasGRP1 and Ras